Zulfeen, Momina published the artcileIV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy-A randomized controlled trial, Category: pyridine-derivatives, the main research area is hypertension pregnancy labetalol nifedipine intravenous oral drug delivery system; Hypertension; Labetalol; Nifedipine; Preeclampsi; Pregnancy.
We conducted a parallel double-blinded randomized controlled trial between Dec. 2014 to Dec. 2016 in 120 antenatal women of gestational age >28 wk, admitted with severe hypertension of blood pressure â?60/110 mm Hg to maternity ward at a tertiary hospital. The labetalol group received 20 mg initially followed by escalating doses of 40 mg, 80 mg, 80 mg and 80 mg (5 doses) every 15 min to a maximum of 300 mg. Nifedipine group received 10 mg initially followed by repeated doses of 20 mg every 15 min (total 5 doses) to a maximum of 90 mg. Vital signs were recorded every 15 min.-The time taken and the number of doses required to achieve the target blood pressure (150/100 mmHg). Survival anal. was used to compare the efficacy of treatment regimens. Sixty women were randomised to each group and none were lost to follow-up. None of the patients in nifedipine group required labetalol, whereas three patients in labetalol group achieved target BP only after receiving nifedipine was administered after the maximum dose of labetalol. The mean time taken to achieve the target blood pressure in the labetalol group was higher (36.75 min) than in the nifedipine group (27.25 min) [mean difference 9.5 min,p = 0.002]. Nifedipine group required significantly lower doses (1.82 ± 0.83) as compared to labetalol (2.45 ± 1.32) [p = 0.002]. Nifedipine was 1.8 times more likely to achieve target blood pressure (Hazard Ratio = 1.8).
European Journal of Obstetrics & Gynecology and Reproductive Biology published new progress about Antihypertensives. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Category: pyridine-derivatives.