Pyka-Pajak, Alina published the artcileComparison of the utility of RP-TLC technique and different computational methods to assess the lipophilicity of selected antiparasitic, antihypertensive, and anti-inflammatory drugs, Computed Properties of 72509-76-3, the main research area is antiparasitic anti inflammatory drug lipophilicity RP TLC technique; Ościk’s equation; Soczewiński–Wachtmeister’s equation; anti-inflammatory drugs; antihypertensive drugs; antiparasitic drugs; lipophilicity.
The aim of this study was to assess the lipophilicity of selected antiparasitic, antihypertensive and non-steroidal anti-inflammatory drugs (NSAIDs) by means of reversed phase-thin layer chromatog. (RP-TLC) as well by using Soczewinski-Wachtmeister’s and J. Oscik’s equations. The lipophilicity parameters of all examined compounds obtained under various chromatog. systems (i.e., methanol-water and acetone-water, resp.) and those determined on the basis of Soczewinski-Wachtmeister’s and Oscik’s equations (i.e., RMWS and RMWO) were compared with the theor. ones (e.g., AlogPs, AClogP, milogP, AlogP, MlogP, XlogP2, XlogP3) and the exptl. value of the partition coefficient (logPexp). It was found that the RMWS parameter may be a good alternative tool in describing the lipophilic nature of biol. active compounds with a high and low lipophilicity (i.e., antihypertensive and antiparasitic drugs). Meanwhile, the RMWO was more suitable for compounds with a medium lipophilicity (i.e., non-steroidal anti-inflammatory drugs). The chromatog. parameter f0(a) can be helpful for the prediction of partition coefficients, i.e., AClogP, XlogP3, as well as logPexp of examined compounds
Molecules published new progress about Antihypertensives. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Computed Properties of 72509-76-3.