Wu, Haixi published the artcileCase report: concurrence of dermatomyositis and autoimmune blistering diseases: two case reports and a literature review, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is prednisone methotrexate minocycline halometasone dermatomyositis autoimmune blistering disease; autoimmune blistering disease; bullous dermatomyositis; clinically amyopathic dermatomyositis; dermatomyositis; interstitial lung disease; malignancy.
Dermatomyositis (DM) is an idiopathic inflammatory myopathy primarily involving skin and muscles. Clin. amyopathic dermatomyositis (CADM), a subset of DM, presents with characteristic cutaneous manifestations without clin. evidence of myositis. Although rare, vesiculobullous eruptions could develop in DM patients. Such ‘bullous DM’ is commonly considered a sign of internal malignancy. However, some cases with similar presentations were diagnosed as autoimmune blistering disease eventually. Herein, we reported two cases of CADM with autoimmune blisters formed. Case 1 presented with vesicles and was diagnosed with CADM initially. However, this patient developed blisters again years later and was diagnosed with ‘pemphigus foliaceous’ (PF) accordingly. Case 2, with a history of nasopharyngeal carcinoma and CADM, developed bullous pemphigoid several days after using a heat patch on her abdomen. The association between disease occurrence and local skin damage might provide more evidence to support the ‘epitope spreading’ hypothesis. Moreover, we reviewed related literature and discussed the differences between the two disease entities in clin. presentations, pathogenesis, therapy, and the risk of complications.
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