Reference of 6969-71-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6969-71-7, name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one. This compound has unique chemical properties. The synthetic route is as follows.
2-(3-Bromopropyl-1,1,3,3-d4)-[1,2,4}triazolo[4,3-a]pyridin-3(2H)-one: A mixture of [1,2,4]triazolo[4,3-a]pyridin-3-(2H)-one (0.300 g, 2.22 mmol), 1,3-dibromopropane-1,1,3,3-d4 (0.453 g, 2.20 mmol), potassium carbonate (1.220 g, 8.88 mmol) and acetonitrile (10 mL) was heated at about 60 C. for about 18 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo, and the resulting crude residue was purified by column chromatography on neutral alumina (15% ethyl acetate in petroleum ether) to yield the title product as an off-white solid (0.180 g, 31%). 1H NMR (400 MHz, CDCl3) delta 2.39 (s, 2H), 6.47-6.53 (m, 1H), 7.07-7.12 (m, 2H), 7.77 (d, J=7.2 Hz, 1H); IR (KBr) nu 3094, 3045, 1710, 1637, 1531, 1437, 1348 cm-1; MS 260, 262 [(M+1), (M+3)].
According to the analysis of related databases, 6969-71-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2009/209550; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem