Ghalehshahi, Hajar G.’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 352 | CAS: 17281-59-3

Ghalehshahi, Hajar G. published the artcileSynthesis, CYP 450 evaluation, and docking simulation of novel 4-aminopyridine and coumarin derivatives, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(3), n/a, database is CAplus and MEDLINE.

Four series of novel compounds based on 4-aminopyridine, glatiramer acetate, pyrone, and coumarin backbones were sufficiently synthesized and identified by spectroscopic methods. CYP enzyme inhibition assays of five predominate human P 450 isoenzymes indicate that all compounds, except for 4-hydrazide pyridine 1c, seem to be less toxic than 4-aminopyridine. Further investigation of the compounds using mol. docking experiments revealed different, the same, or stronger binding modes for most of the synthesized compounds, with both polar and hydrophobic interactions with the 1WDA and 1J95 receptors compared to benzoyl L-arginine amide and 4-aminopyridine, resp. These results introduce the synthesized compounds as K⁺ channel blockers that could be considered for in vivo CNS disease studies.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem