Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5F3N2, blongs to pyridine-derivatives compound. Formula: C6H5F3N2
Thionyl chloride (31 mL, 0.43 mol) was slowly added to 175 mL, of water at 0 C. During the addition the temperature was maintained between 0-5 C. After addition the solution was warmed to 15 C. and 0.47 g (4.8 mmol) of CuCl was added. The solution was diluted with 100 mL of water and cooled back to 0 C. A solution of 7.21 g (0.10 mol) of NaNO2 in 100 mL, of water was slowly added to a solution of 15.39 g (0.10 mol) of 5-amino-2-(trifluoromethyl)pyridine (95) in 125 mL of conc. HCl at 0 C. During addition the temperature was maintained between 0-5 C. This mixture was then slowly added to the above prepared solution so as to maintain a temperature between 0-5 C. A voluminous precipitate formed. The mixture was stirred for an additional 30 min after addition and the solid was then collected by filtration. The solid was washed with water and dissolved in CHCl3. The solution was dried over MgSO4, filtered and the solvent was removed to afford 18.03 g (77%) of sulfonyl chloride (83) as a tan solid. 1H NMR (CDCl3) delta 9.34 (d, J=2.2 Hz, 1 H), 8.53 (dd, J=8.4, 2.2 Hz, 1H), 7.98 (d, J=8.4 Hz, 1H).
The synthetic route of 106877-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Konradi, Andrei W.; Probst, Gary; Aubele, Danielle L.; Garofalo, Albert W.; Hom, Roy; Neitzel, Martin L.; Semko, Christopher M.; Truong, Anh P.; US2008/21056; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem