Hertog, Adriaan Den published the artcileThe action of some new aminopyridines on mammalian nonmyelinated nerve fibers, Application In Synthesis of 18437-58-6, the publication is European Journal of Pharmacology (1987), 142(1), 115-20, database is CAplus.
The effects of a recently synthesized series of aminopyridines (APs) 2-methyl-4-AP, 2-chloro-4-AP, and 2-(N,N-methylbenzyl)amino-4-AP (2A-7) on voltage-operated Na+ and K+ channels and on the Na+ pump activity of nonmyelinated fibers of the guinea-pig vagus nerve were studied with the sucrose-gap method. The compound action potential evoked by elec. stimulation and the propagation velocity along the nerve were not affected by 2-methyl-4-AP or 2-chloro-4-AP up to a concentration of 10-3 M. The post-tetanic potential (PTH) evoked by repetitive stimulation of the nerve and reflecting Na+ pumping was also not affected by these agents. The amplitude and duration of the compound action potential were enhanced to some extent by 2-methyl-4-AP at the highest concentration used (3 × 10-3 M); this action was also observed and was more pronounced with 4-aminopyridine (4-AP). The other aminopyridine 2A-7 (3 × 10-5-3 × 10-4 M) caused suppression of the compound action potential, a diminished propagation velocity and a reduction of the PTH, an action also observed with lidocaine. These results show that 2-methyl-4-AP and 3-chloro-4-AP did not affect the voltage-operated Na+ or K+ channels in nonmyelinated fibers of the vagus nerve. Only 2-methyl-4-AP had a small 4-AP-like action at high concentrations The aminopyridine 2A-7 possesses a local anesthetic action as reflected by the inhibition of voltage-operated Na+ channels.
European Journal of Pharmacology published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem