Mdluli, Velabo published the artcileHigh-throughput Synthesis and Screening of Iridium(III) Photocatalysts for the Fast and Chemoselective Dehalogenation of Aryl Bromides, Computed Properties of 85237-71-4, the publication is ACS Catalysis (2020), 10(13), 6977-6987, database is CAplus.
A high-throughput optical screening method for the photocatalytic activity of a structurally diverse library of 1152 cationic iridium(III) complexes ([Ir(C^N)2(N^N)]+), corresponding to all combinations of 48 cyclometalating (C^N) and 24 ancillary (N^N) ligands, was developed. This rapid assay utilizes the colorimetric changes of a high contrast indicator dye, coumarin 6, to monitor the photo-induced electron transfer from a sacrificial amine donor to the metal complex excited state. The resulting [Ir(C^N)2(N^N)]0 can then reduce an aryl bromide to form the highly reactive aryl radical intermediate. The rate of this reaction is dictated by the mol. structure of both coordinating ligands. Relative reaction rate constants determined via this method correlated closely with 19F NMR measurements obtained using a fluorinated substrate. A simple model that expresses the rate constant as a product of a single ”strength” parameter assigned to each of the 72 ligands can well account for the 1152 measured rate constants The best performing complexes exhibit much higher reactivity than the benchmark photocatalysts commonly used in photoredox transformations. The catalysts were also successfully tested for their chemoselectivity. The developed screening methodol. can enable generation of the large data sets needed to use modern data science to extract structure-activity relationships.
ACS Catalysis published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Computed Properties of 85237-71-4.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem