Synthetic Route of 101990-70-9, Adding some certain compound to certain chemical reactions, such as: 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101990-70-9.
tert-Butyl (5S)-2-[(6-methoxypyridin-3-yl)methyl]-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate tert-Butyl (5S)-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate (1.33 g, 5.55 mmol) was initially charged in acetonitrile (30 ml). Caesium carbonate (4.52 g, 13.9 mmol), 5-(chloromethyl)-2-methoxypyridine (963 mg, 6.11 mmol) and sodium iodide (5.00 mg, 0.03 mmol) were subsequently added. After stirring for 4 days, the reaction mixture was admixed at room temperature with water and ethyl acetate. The organic phase was removed and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and filtered, and the filtrate was concentrated. The residue was purified via column chromatography (silica gel, eluent: cyclohexane/ethyl acetate gradient). The product-containing fractions were concentrated under reduced pressure, and 751 mg (37% of theory) of the title compound were obtained. LC-MS (Method 3): Rt=1.56 min; MS (ESIpos): m/z=361 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.385 (16.00), 2.048 (0.54), 2.058 (0.48), 2.525 (0.41), 3.825 (6.81), 4.424 (0.60), 4.791 (2.68), 6.785 (0.78), 6.807 (0.84), 7.574 (0.51), 7.580 (0.52), 7.595 (0.49), 7.602 (0.50), 8.074 (0.67), 8.080 (0.65).
According to the analysis of related databases, 101990-70-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; BIBER, Nicole; BROCKSCHNIEDER, Damian; GERICKE, Kersten Matthias; KOeLLING, Florian; LUSTIG, Klemens; MEDING, Joerg; MEIER, Heinrich; NEUBAUER, Thomas; SCHAeFER, Martina; TIMMERMANN, Andreas; ZUBOV, Dmitry; TERJUNG, Carsten; LINDNER, Niels; BADOCK, Volker; MOOSMAYER, Dieter; MIYATAKE ONDOZABAL, Hideki; MOORE, Steven; SCHULZ, Alexander; (458 pag.)US2019/160048; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem