Al-Sanea, Mohammad M. published the artcileSynthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents, Application of (6-Ethoxypyridin-3-yl)boronic acid, the publication is Molecules (2015), 20(1), 1031-1045, 15 pp., database is CAplus and MEDLINE.
A series of phenyl(bipyridinyl)pyrazoles I (R = F, MeS, morpholin-4-yl, etc.) were synthesized and screened at 10 μM against over 60 tumor cell lines at the U.S. National Cancer Institute (NCI). Compounds I [R = pyrrolidin-1-yl, 4-benzylpiperazin-1-yl (II)] showed a broad spectrum of activity against NCI cell lines with mean growth of 53% and 58%, resp. Compound I [R = 4-methylpiperazin-1-yl (III)] behaved differently as it showed a high degree of selectivity and potency by inhibiting 96% of growth of leukemia SR cell line at 10 μM. Standard COMPARE anal. was performed at the GI50 level and the results exhibited a high correlation in the form of pairwise correlation coefficient (PCC) of more than 0.6 between three of the current compounds and three standard known anticancer agents. Compound III demonstrated a high correlation level with merbarone (NSC S336628) with a PCC value of 0.631. Compound II showed a considerably high PCC value of 0.626 with dichloroallyl lawsone, while compound I (R = benzyloxy), showed PCC values of 0.601 and 0.604 with both dichloroallyl lawsone and N,N-dibenzyldaunomycin (NSC S268242), resp. These three standard agents have anticancer activity via two major mechanism of actions, inhibition of topoisomerase II and inhibition of biosynthesis of pyrimidine nucleotides, therefore, compounds I are promising therapeutic agents for targeting different human malignancies. Prediction of drug-likeness and toxicity of the synthesized derivatives I were also considered.
Molecules published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Application of (6-Ethoxypyridin-3-yl)boronic acid.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem