Moise, Iuliana-Monica’s team published research in Tetrahedron in 76 | CAS: 17281-59-3

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Moise, Iuliana-Monica published the artcileSwitching the reactivity of cyanomethylpyridinium salts in the 1,3-cycloaddition conditions with alkyl propiolates to cyanoindolizines or cyanoazaindolizinyl-indolizines, Related Products of pyridine-derivatives, the publication is Tetrahedron (2020), 76(41), 131502, database is CAplus.

A particular reactivity of 1-cyanomethylpyridinium salts was revealed in the [3 + 2] cycloaddition conditions with alkyl propiolates. Cyanoindolizines I [R = H, 7-Me, 7-OMe, etc.] were obtained in reactions carried out at room temperature while refluxing in CH3CN provided unexpected Et or Me 3-(3-cyanoimidazo[1,2-a]pyridin-2-yl)indolizine-1-carboxylates II. The structure of the new 2:1 azaindolizine-indolizine adducts was secured by X-ray anal. Methodol. efforts had enabled the adjustment of the reactivity towards the formation of 3-cyanoindolizines I or cyanoazaindolizine-indolizines II. A mechanism for the formation of azaindolizine-indolizines was proposed.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem