Extended knowledge of 6-Oxo-1,6-dihydropyridine-2-carboxylic acid

According to the analysis of related databases, 19621-92-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 19621-92-2, Adding some certain compound to certain chemical reactions, such as: 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19621-92-2.

Ethyl iodide (112.2 g, 720 mmol, 4 equiv) was added to a suspension of 6-hydroxy – pyridme-2-carboxylic acid (25.0 g, 180 mmol, 1 equiv) and silver(I) carbonate (100 g, 360 mmol, 2 equiv) in CHCb (400 mL). The mixture was stirred at 30C for 1 day. Insoluble material was removed by filtration and the solid was washed with CHCb. The filtrate was concentrated in vacuo to afford the title compound ethyl 6-ethoxypicolinate as light yellow oil which was used in the next step without further purification. LC-MS: m/z 196.0 (M+H) +

According to the analysis of related databases, 19621-92-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANNAPURNA BIO, INC.; TANG, Haifeng; HANSON, Michael; BOYCE, Sarah; NIE, Zhe; (461 pag.)WO2020/73011; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem