Adding a certain compound to certain chemical reactions, such as: 1628-89-3, 2-Methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1628-89-3, blongs to pyridine-derivatives compound. COA of Formula: C6H7NO
A solution of 2-methoxy-pyridine (100 g, 0.92 mole), NBS (180 g, 1.0 mole) inacetonitrile (1. OL) was stirred at reflux for 21 h. TLC showed that the reaction wascomplete. The reaction mixture was cooled to room temperature and concentrated. 900ml solvent was collected. The resulting suspension was filtered and washed with n-hexane (400mL). The filtrate was concentrated again to afford crude product. The cmde product was distilled at reduced pressure (30C[-0.3mmHg) to afford the title compound as a clearoil (146 g, 84%). LCMS (m/z): 190.0 [M+1f ?H NMR (400 MHz, CDC13): oe 3.90 (s,3H), 6.65 (d, J= 8.8 Hz, 1H), 7.62 (dd, J= 8.8 Hz, 2.4Hz, 1H), 8.19 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1628-89-3, its application will become more common.
Reference:
Patent; CURIS, INC.; FATTAEY, Ali; RHYASEN, Garrett, W.; (61 pag.)WO2018/85342; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem