New downstream synthetic route of 1H-Pyrrolo[2,3-c]pyridin-5-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,174610-12-9, its application will become more common.

Application of 174610-12-9 ,Some common heterocyclic compound, 174610-12-9, molecular formula is C7H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 5 (200 mg, 0.450 mmol) , 1H-pyrrolo [2, 3-c] pyridin-5-amine (120 mg, 0.90 mmol) , palladium (II) acetate (50 mg, 0.225 mmol) , xantphos (196 mg, 0.340 mmol) and potassium carbonate (124 mg, 0.90 mmol) in 1, 4-dioxane (10 mL) under heating at 100 through microwave irradiation for 1 hour under N2 atmosphere. LC-MS: m/z 539.2 (M+H) +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,174610-12-9, its application will become more common.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem