Related Products of 3731-52-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3731-52-0, name is Pyridin-3-ylmethanamine, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.
PREPARATION 19; Preparation of 2-bromo-4-methyl-vV-(pyridin-3-ylmethyl)thiazole-5-carboxamide; To a solution of 2-bromo-4-methylthiazole-5-carboxylic acid ( 10.00 g, 45.00 mmol) and 4-methylmorpholine (6.5 mL, 59.0 mmol) in tetrahydrofuran ( 150 mL) was added isobutyl chloroformate (6.5 mL, 49.6 mmol) at 0 0C. The resulting mixture was stirred at room temperature for 1 hour and 3-(aminomethyl)pyridine (5.2 mL, 51.4 mmol) was added. The reaction mixture was stirred at ambient temperature for 17 hours, and then concentrated in vacuo. The residue was purified by column chromatography to afford 2-bromo-4-methyl-jV-(pyridin-3-ylmethyl)thiazole-5-carboxamide in 52% yield (7.3 g): 1H NMR (300 MHz, CDCl3) delta 8.39-8.80 (m, 2H), 7.80-7.72 (m, IH), 7.40-7.35 (m, I H), 6.47 (br s, I H), 4.60 (d, J= 6.0 Hz, 2H), 2.64 (s, 3H); MS (ES+) we 312.1 (M + 1 ), 314.1 (M + 1 ).
Statistics shows that 3731-52-0 is playing an increasingly important role. we look forward to future research findings about Pyridin-3-ylmethanamine.
Reference:
Patent; NOVARTIS AG; XENON PHARMACEUTICALS INC.; WO2008/127349; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem