Norman, Mark H. published the artcileStructural elucidation of an oxazolo[5,4-b]pyridine: an alternative cyclization product related to nevirapine, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is mol structure oxazolopyridine; nevirapine derivative; pyridooxazole structure; crystal structure oxazolopyridine.
An unexpected cyclization product was isolated in the final step of the synthesis of nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. Based on IR spectrometry, mass spectrometry, and a number of two-dimensional NMR experiments, the structure of this product was assigned to be 2-((2-cyclopropylamino)-3-pyridyl)-7-methyloxazolo[5,4-b]pyridine. Results of a single crystal X-ray anal. confirmed this structural assignment. This product arises from cyclization of N-(2-chloro-4-methyl-3-pyridyl)-2-(cyclopropylamine)-3-pyridinecarboxamide, 8, by displacement of the chlorine with the amide carbonyl oxygen. A competitive reaction occurs when 8 is deprotonated prior to cyclization to form nevirapine, 11-cyclopropyl-5,11-dihydro-4-methyl-6H- dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one.
Journal of Heterocyclic Chemistry published new progress about Crystal structure. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.