Zhao, Lifeng published the artcileNovel small molecules as apoptosis inducers: Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation, COA of Formula: C6H7ClN2, the main research area is small mol apoptosis inducer preparation structure activity relationship bioactivity.
Inducing apoptosis is a promising therapeutic approach to overcome cancer. In this study, 30 compounds were synthesized and evaluated for their antiproliferative activity against three tumor cell lines in vitro: A875, H460 and Hela cancer cells by the MTT assay. The most potent compound discovered by our group inhibited the proliferation of A875 cells with an IC50 value of 98 nM. Flow cytometry anal. and morphol. anal. suggested that said compound had potential anticancer efficacy via G2/M cell cycle arrest. The SAR anal. was also performed.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.