Perry, Matthew W. D. published the artcileDiscovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma, Related Products of pyridine-derivatives, the main research area is AZD8154 PI3K gamma delta inhibitor asthma inhaled.
Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the mols., including macrocyclization, but ultimately identified a simpler series with the desired potency profile that had suitable physicochem. properties for inhalation. We were able to demonstrate efficacy in a rat ovalbumin challenge model of allergic asthma and in cells derived from asthmatic patients. The optimized compound, AZD8154, has a long duration of action in the lung and low systemic exposure coupled with high selectivity against off-targets.
Journal of Medicinal Chemistry published new progress about Allergic asthma. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Related Products of pyridine-derivatives.