Application of 110860-92-9 ,Some common heterocyclic compound, 110860-92-9, molecular formula is C5H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 1 3-(2-chloro-1,1,2-trifluoroethoxy)-5,6-dichloropyridine Chlorotrifluoroethylene was passed into a mixture of 16.4 g (0.1 mol) of 5,6-dichloro-3-pyridinol I/29 and 20 g (0.145 mol) of anhydrous potassium carbonate in 100 ml of absolute acetonitrile at 35 C. until starting material was no longer present. The solid was filtered off under suction, the solvent was removed by distillation, and the residue was taken up in ether and washed until neutral. After drying over MgSO4 and removal of the ether by distillation, the residue was distilled in a high vacuum. Yield 83% Boiling point 85 C./0.03 mbar
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110860-92-9, its application will become more common.
Reference:
Patent; Hoechst Aktiengesellschaft; US4756739; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem