Reference of 5344-27-4 , The common heterocyclic compound, 5344-27-4, name is 4-(2-Hydroxyethyl)pyridine, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 76; N-{5-amino-3-cyano-1-[2, 6-dichloro-4-pentafluorothiophenyl]-1 H-pyrazol-4-yl}-N-(2- pyridin-4-ylethyl) methanesulfonamide; A mixture of Example 38 (200 mg, 0.42 mmol), 4- (2-hydroxyethyl) pyridine (52 mg, 0.42 mmol) and triphenylphosphine (167 mg, 0.64 mmol) in anhydrous tetrahydrofuran (5 ml) was cooled to 0C and diethyl azodicaboxylate (0.1 ml, 0.64 mmol) was added. The reaction mixture was warmed to room temperature and stirred under nitrogen overnight. The reaction mixture was concentrated in vacuo and the residue was partitioned between dichloromethane and water. The organic phase was then separated, dried and concentrated in vacuo. The residue was dissolved in acetonitrile/water (4 ml) and the solution was purified by automated preparative liquid chromatography (Gilson system, 150 x 30 mm, LUNA II C18 10 lim column) using an acetonitrile : 0. 1% trifluoroacetic acid gradient [35: 65 to 95: 5]. The appropriate fractions were concentrated to give the titled compound (55 mg). Experimental MH+ 577.0 ; expected 577.0 ‘H-NMR (CD03) : 2.99-3. 04 (3H), 3.11-3. 18 (2H), 4.12-4. 17 (2H), 4.19-4. 41 (2H), 7.62-7. 69 (2H), 7.86-7. 89 (2H), 8.59-8. 67 (2H)
The synthetic route of 5344-27-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/90313; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem