Adding a certain compound to certain chemical reactions, such as: 159451-66-8, N-Boc-2-Amino-5-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: N-Boc-2-Amino-5-bromopyridine, blongs to pyridine-derivatives compound. Recommanded Product: N-Boc-2-Amino-5-bromopyridine
To a mixture of anhydrous CuCN (2.7 g, 30.4 mmol) in 100 mL of THF was added a solution of tert-butylmagnesium chloride (30.4 mL, 60.2 mmol, 2M solution in THF) under N2 at -78 C. After 20 minutes, tert-butyl 5-bromopyridin-2-ylcarbamate (2.1 g, 7.6 mmol, Aldrich) was added. The reaction mixture was stirred for 2 hours at -78 C. and then at room temperature for 12 hours. The mixture was quenched with saturated aqueous NH4OH and basified to pH 7 with 20% aqueous NaOH. The solid was filtered through a pad of Celite. The filtrate was extracted with ether and washed with water. The organic extract was dried over MgSO4 and concentrated. Purification by column chromatography (SiO2: 0-15% hexanes/ethyl acetate gradient) afforded 0.4 g of the title compound. MS (ESI+) m/z 251 (M+H)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,159451-66-8, N-Boc-2-Amino-5-bromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem