Takaoka, Ryota published the artcileModel-based meta-analysis of changes in circulatory system physiology in patients with chronic heart failure, SDS of cas: 72509-76-3, the main research area is meta analysis chronic heart failure circulatory system.
Meta-anal. of changes in circulatory system physiol. in patients with chronic heart failure. To characterize and compare various medicines for chronic heart failure (CHF), changes in circulatory physiol. parameter during pharmacotherapy were investigated by a model-based meta-anal. (MBMA) of circulatory physiol. The clin. data from 61 studies mostly in patients with heart failure with reduced ejection fraction (HFrEF), reporting changes in heart rate, blood pressure, or ventricular volumes after treatment with carvedilol, metoprolol, bisoprolol, bucindolol, enalapril, aliskiren, or felodipine, were analyzed. Seven cardiac and vasculature function indexes were estimated without invasive measurements using models based on appropriate assumptions, and their correlations with the mortality were assessed. Estimated myocardial oxygen consumption, a cardiac load index, correlated excellently with the mortality at 3, 6, and 12 mo after treatment initiation, and it explained differences in mortality across the different medications. The anal. based on the present models were reasonably consistent with the hypothesis that the treatment of HFrEF with various medications is due to effectively reducing the cardiac load. Assessment of circulatory physiol. parameters by using MBMA would be insightful for quant. understanding of CHF treatment.
CPT: Pharmacometrics & Systems Pharmacology published new progress about Blood pressure. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, SDS of cas: 72509-76-3.