Achim, Marcela published the artcilePreparation and in vitro evaluation of felodipineloaded poly(ε-caprolactone) microspheres: quality by design approach, Category: pyridine-derivatives, the main research area is felodipine polycaprolactone microsphere polydispersity index drug development.
Felodipine was encapsulated into poly(ε-caprolactone) microspheres by the emulsion solvent evaporation method by employing the Quality by Design (QbD) strategy. Based on a risk anal., the influence of 4 critical process parameters (type of stirrer, stirring rate, shape of mixing vessel, aqueous phase volume) on the critical quality attributes of the microspheres (size, polydispersity, entrapment efficiency (EE)), was evaluated by a full factorial exptl. design. The microspheres’ morphol. and felodipine in vitro release were also studied. The particles’ size ranged between 39.8 and 302.5μm, and the polydispersity index varied from 0.279 to 0.517. Felodipine EE was above 93.59%. SEM (SEM) anal. revealed spherical particles, with imperfections and micropores on the surface. The microspheres exhibited an extended release of felodipine over a period of 12 h. In conclusion, the QbD approach helped understand the process parameters and their impact on the quality profile in the development of felodipine-loaded microspheres.
Farmacia (Bucharest, Romania) published new progress about Drug discovery. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Category: pyridine-derivatives.