Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13534-99-1, name is 2-Amino-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H5BrN2
Ethyl isocyanatoformate (52.5?g, 397?mmol) is added dropwise at 5?C to a solution of 2-amino-3-bromopyridine (33a) (66?g, 378?mmol) in DCM (660?mL). After stirring for 16?h at RT the reaction mixture is concentrated under reduced pressure to give crude product, which is washed with PE and dried. Yield: 105?g (87%). LCMS (ESI+) calculated for C9H10BrN3O2S [M+H]+ m/z 303.9755, found 304.0. 1H NMR (400?MHz, (CD3)2SO) delta 11.43 (br s, 2H), 8.49 (dd, J?=?4.6, 1.5?Hz, 1H), 8.17 (dd, J?=?7.9, 1.5?Hz, 1H), 7.33 (dd, J?=?7.9, 4.7?Hz, 1H), 4.23 (q, J?=?7.1?Hz, 2H), 1.27 (t, J?=?7.1?Hz, 3H). TLC (silica gel, PE/EE 3:1): Rf?=?0.4.fx8
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Reference:
Article; Gerlach, Kai; Hobson, Scott; Eickmeier, Christian; Gross, Ulrike; Braun, Clemens; Sieger, Peter; Garneau, Michel; Hoerer, Stefan; Heine, Niklas; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3227 – 3241;,
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