Synthetic Route of 884495-14-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-14-1, name is 5-Bromo-2-methoxy-4-methyl-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 5-bromo-2-methoxy-4-methyl-3-nitro-pyridine (2.0 g, 8.1 mmol), bis(pinacolato)diboron (10.28 g, 40.48 mmol), [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (1.19 g, 1.62 mmol) and potassium acetate (2.38 g, 24.29 mmol) in 1,4-dioxane (40 mL) was stirred at 100 C. for 2 hours. The mixture was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with petroleum ether/ethyl acetate (1/1) to afford 2-methoxy-4-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (2.1 g, 7.14 mmol) as a yellow solid. LCMS (ESI) [M+H]+=295.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 884495-14-1, 5-Bromo-2-methoxy-4-methyl-3-nitropyridine.
Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem