Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. A new synthetic method of this compound is introduced below., COA of Formula: C5H2Br2N2O2
Methanesulfinic acid sodium salt (1.66 g, 16.3 mmol) is added to a solution of 2,6- dibromo-4-nitropyridine (0.917 g, 3.253 mmol) and DMF (15 ml_). After 1 h the DMF is removed in vacuo and the residue is taken up in CH2CI2 (150 ml.) and brine (150 ml_). The layers are mixed and then separated. The aqueous layer is extracted further with CH2CI2 (2 x 150 ml_). The combined organic layers are then dried (Na2SO4), filtered and concentrated. The residue is then separated via flash chromatography (SiO2, 5-30% EtOAc/heptane gradient) to give the title compound 2,6-dibromo-4-methanesulfonylpyridine as a white powder. MS (ESI) m/z 316.2 (M+1 ). 1H NMR (400 MHz, CDCI3) delta ppm 7.94 (s, 2 H), 3.12 (s, 3 H).
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Reference:
Patent; NOVARTIS AG; WO2009/150230; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem