Synthetic Route of 77168-63-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.77168-63-9, name is 4-(Pyridin-4-yl)thiazole-2-thiol, molecular formula is C8H6N2S2, molecular weight is 194.28, as common compound, the synthetic route is as follows.
Reference Example 6 4-(4-pyridyl)-1,3-thiazole-2-thiol sodium salt 4-(4-Pyridyl)-1,3-thiazole-2-thiol (194 g, 1.0 mol) was suspended in methanol (1 L) and a powder of sodium methylate (71.5 g, 1.2 mol) was added at 25OEC. The mixture was stirred for 30 min and the reaction mixture was concentrated under reduced pressure to 50-60 mL. The mixture was preserved overnight in a refrigerator. The precipitated crystals were collected by filtration and dried in vacuo in the presence of phosphorus pentoxide at 40OEC to give the title compound (160 g, 0.74 mol). yield: 74percent.
Statistics shows that 77168-63-9 is playing an increasingly important role. we look forward to future research findings about 4-(Pyridin-4-yl)thiazole-2-thiol.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1310502; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem