As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19437-26-4, name is Di(pyridin-2-yl)methanone, molecular formula is C11H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
A mixture of p-toulenesulphonyl hydrazine (200 mg,1.29 mmol) and dipyridyl ketone (238 mg, 1.29 mmol) alongwith two drops of glacial acetic acid was refluxed inmethanol for 6 h (Scheme 1). The solvent was removed usingrotavapor and the product, yellow oily mixture was passedthrough silica gel column using hexane and methanol (1:1)as solvents. The compound was obtained as yellow solid.M.p.: 160C. Yield: (75%). FTIR (KBr pellet, cm-1): 3079nu(C-H), 1631 nu(C=N), 1601 nu(C=C). 1H NMR (DMSO-d6, 400MHz, delta, ppm): 9.24 (d, 1H, JHH = 7.2 Hz), 8.75 (d, 1H,JHH = 4.4 Hz), 8.53 (d, 1H, JHH = 8.8 Hz), 8.37 (d, 1H,JHH = 7.6 Hz), 8.20-8.13 (m, 2H), 7.67 (t, 1H, JHH = 7.6Hz), 7.36 (t, 1H, JHH = 7.6 Hz). UV/Vis (MeOH) lambdamax, nm(epsilon, M-1 cm-1) = 222 (2.12 ¡Á 105), 264 (1.0 ¡Á 105), 306(1.21 ¡Á 105). HRMS (ESI) m/z: calcd.: 196.0749, found: 197.0851 [M+H]+. Anal. Calcd. (%) for C11H8N4C, 67.34;H, 4.11; N, 28.55. Found (%): C, 67.64; H, 3.91; N, 28.75.
With the rapid development of chemical substances, we look forward to future research findings about 19437-26-4.
Reference:
Article; Palepu, Narasinga Rao; Kollipara, Mohan Rao; Journal of Chemical Sciences; vol. 129; 2; (2017); p. 177 – 184;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem