New downstream synthetic route of (4,6-Dichloropyridin-3-yl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73998-95-5, (4,6-Dichloropyridin-3-yl)methanol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73998-95-5, name is (4,6-Dichloropyridin-3-yl)methanol, molecular formula is C6H5Cl2NO, molecular weight is 178.02, as common compound, the synthetic route is as follows.Computed Properties of C6H5Cl2NO

^-Dichloro-S-trichloromethyl-pyridine:; To a solution of (4,6-dichIoropyridin-3-yl)methanol (7 g, 39 mmol) in CCl4 (200 mL), was added sulfuryl dichloride (120 mL) dropwise with stirring. The resulting solution was heated at reflux overnight. The mixture was concentrated and the pH was adjusted to pH 8 by the addition OfNaHCO3 (2N). The resulting solution was extracted with EtOAc (2 x 100 mL) and the organic layers were combined and dried over Na2SO4. The residue was purified bysilica gel column chromatography to afford 1.2 g (12%) of 2,4-dichloro-5-(trichloromethyl)pyridine.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73998-95-5, (4,6-Dichloropyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven; WO2006/55187; (2006); A1;,
Pyridine – Wikipedia,
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