Synthetic Route of 67625-37-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67625-37-0, name is Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 30 (8 g, 29.73 mmol), 2-chlorobenzaldehyde (6.7 ml, 59.58 mmol),2,2-dimethyl-1,3-dioxane-4,6-dione (8.6 g, 59.67 mmol), L-proline (170 mg, 1.48 mmol)and MgSO4 (11 g, 91.39 mmol) in acetonitrile (80 mL) was heated at 90 C for 33 h, followed by 100 C 15h. The reaction cooled to r.t., and the solid filtered off, and washed with methanol (2 x 50 mL). The filtrate was concentrated in vacuo and triturated with diethyl ether (50 mL) and sonicated for 1 0mm and resulting gum was filtered off andrinsed with diethyl ether (2 x 50 mL) yielding the title compound as beige solid (10.2g,76%). 1H NMR (500 MHz, Methanol-d4) oe 8.79 (s, 1H), 7.74 (d, J 7.7 Hz, 1H), 7.67 -7.55 (m, 2H), 7.43 – 7.34 (m, 2H), 7.34 – 7.20 (m, 1H), 5.56 (dd, J 9.5, 6.0 Hz, 1H), 4.35(qt, J 7.4, 3.7 Hz, 2H), 3.70 (dd, J 16.7, 9.5 Hz, 1H), 3.40 (dd, J 16.7, 6.0 Hz, 1H), 1.34(t, J 7.1 Hz, 3H). LCMS (ESj RT 1.24 mm, 45 1.0/453.0 (M+H)t
According to the analysis of related databases, 67625-37-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB BIOPHARMA SPRL; SANOFI; DE HARO GARCIA, Teresa; DELIGNY, Michael; HEER, Jag Paul; QUINCEY, Joanna Rachel; XUAN, Mengyang; ZHU, Zhaoning; BROOKINGS, Daniel Christopher; CALMIANO, Mark Daniel; EVRARD, Yves; HUTCHINGS, Martin Clive; JOHNSON, James Andrew; JADOT, Sophie; KEYAERTS, Jean; MAC COSS, Malcolm; SELBY, Matthew Duncan; SHAW, Michael Alan; SWINNEN, Dominique Louis Leon; SCHIO, Laurent; FORICHER, Yann; FILOCHE-ROMME, Bruno; (365 pag.)WO2016/50975; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem