Reference of 58481-11-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58481-11-1, name is Methyl 2-chloroisonicotinate, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of methyl 2-chloroisonicotinate (4.59 g, 26.7 mmol) in dry dioxane (120 mL),Pd(dppt) (2.18 g, 2.67 mmol) is added under argon. To this red-brown suspension 3-pentylzink (11.6 g, 53.5 mmol, 107 mL of a 0.5 M solution in THF) is added and the mixture is stirred at 100¡ãC for 18 h. The black solution is cooled to rt, diluted with EA (200 mL) and washed with water (100 mL) and 2 N aq. HCI. The washings are extracted four times with DCM (4×100 mL). The combined org. extracts are dried over MgSO4, filtered andconcentrated. The crude product is purified by MPLC on silica gel eluting with a gradient of EA in heptane to give methyl 2-(pentan-3-yl)isonicotinate (1.15 g, 21percent) as brownish oil containing a few percent of methyl 2-(pentan-2-yl)isonicotinate; LC-MS: tR = 0.62 mm; [M+1] = 208.30. This material is dissolved in THF (30 mL) and 25percent aq. HCI (25 mL) and the mixture is stirred at 70¡ãC for 18 h before it is concentrated and dried to give the title compound (467 mg, 37percent) as a beige solid; LC-MS: tR = 0.35 mi [M+1] = 194.28; 1HNMR (CD3OD): 8.74 (d, J = 5.2 Hz, 1 H), 7.97 (5, 1 H), 7.96 (d, J = 6.0 Hz, 1 H), 2.74-2.84 (m, 1 H), 1.71-1.91 (m, 4 H), 0.83 (t, J = 7.4 Hz, 6 H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58481-11-1, Methyl 2-chloroisonicotinate.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; LESCOP, Cyrille; NAYLER, Oliver; STEINER, Beat; WO2014/141171; (2014); A1;,
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