Kawabata, Atsuhiko published the artcileEffects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Japanese Journal of Pharmacology (1991), 55(1), 101-6, database is CAplus and MEDLINE.
The effects of anti-vertigo drugs on the brain medial vestibular nucleus (MVN) neurons were examined to assess the site and mode of action using cats anesthetized with α-chloralose. Single neuron activity in the MVN was extracellularly recorded using a silver wire microelectrode filled with diphenhydramine, diphenidol, betahistine, glutamate, or NaCl. Type I of the MVN neurons were identified according to the responses obtained when the animal placed on a turn-table was rotated sinusoidally. The drug effects were examined on type I neurons which received impulses primarily from the labyrinth and sent them to the oculomotor nuclei. The microiontophoretic application of diphenhydramine, diphenidol, and betahistine inhibited the rotation-induced firing of type I MVN neurons. Diphenhydramine and diphenidol were more potent than betahistine. These drugs act directly on MVN neurons and reduce the responsiveness to rotatory stimulation.
Japanese Journal of Pharmacology published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem