Ito, Satoru published the artcileDiscovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist, Synthetic Route of 107263-95-6, the publication is Bioorganic & Medicinal Chemistry (2008), 16(22), 9817-9829, database is CAplus and MEDLINE.
We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryltriazol-4-yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chem. modification of the lead compound successfully led to fluoropyridine analogs with improved in vivo antagonistic activities. Among the evaluated compounds, a chem. stable urea analog showed oral antagonistic activity at dose ranges of 10-30 mg/kg in an animal model.
Bioorganic & Medicinal Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Synthetic Route of 107263-95-6.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem