Hanan, Emily J. published the artcileDiscovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10090-10107, database is CAplus and MEDLINE.
The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified the pyrazolo[1,5-a]pyrimidine scaffold as a potent inhibitor of Jak2. Optimization of lead compounds in this chem. series for activity against Jak2, selectivity against other Jak family kinases, and good in vivo pharmacokinetic properties led to the discovery of (I). In a SET2 xenograft model that is dependent on Jak2 for growth, I demonstrated a time-dependent knock-down of pSTAT5, a downstream target of Jak2.
Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem