Electric Literature of 89284-61-7, Adding some certain compound to certain chemical reactions, such as: 89284-61-7, name is 4-Chloronicotinonitrile,molecular formula is C6H3ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89284-61-7.
4- {3- [ 1 -(2 ,2-dimethy Ipropy l)-4-fluoro-3-metby 1-2-0X0-2 s3-dihy d ro- 1 H-benziin id azol-5- yl]phenoxy}nicotinonitrile (8-1)A solution of l-(2,2-dimethylpropyl)-4~fiuoro-5-(3-hydroxyp enyl)-3-methyl-lJ3-dihydro-2H- benzimidazol-2-one (7-15, 55 mg, 0.17 mmol) in DMSO (1 ml) was charged with Potassium carbonate (46.3 mg, 0.34 mmol, 2.0 eq) and 4-Chloro-3-cyanopyridine (34.8 mg, 0.25 mmol, 1.5 eq). The mixture was irradiated in a microwave at 160 deg C for 20 min, then purified via reverse-phase HPLC (Acetonitrile/ Water gradient with 0.1% TFA present) providing 4-{3-[l- (2,2-dimethylpropyl)-4-fluoro-3-metJiyl-2-oxo-253-dihydro-lH-benzimidazol-5- yl]phenoxy}nicotinonitrile (8-1) as a tan solid-oil. 1HNMR (400 MHz, CDC13) 8 8.81 (bs, lH), 7.60-7.53 (m, 2H), 7.35 (s, 1H), 7.27 (s, 1H), 7.17-7.14 (m, 1H), 7.1 1-7.07 (m, 1H), 6.91 (d, 2H, J=8.24 Hz), 3.69 (s, 2H), 3.66 (s, 3H), 1.10 (s, 9H). LRMS m/z: Calc’d for C2sH23FN402 (M+H) 431.4, found 431.5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89284-61-7, 4-Chloronicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.; WO2012/21382; (2012); A1;,
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