Brief introduction of 2-Isopropylpyridine

The synthetic route of 644-98-4 has been constantly updated, and we look forward to future research findings.

Electric Literature of 644-98-4 , The common heterocyclic compound, 644-98-4, name is 2-Isopropylpyridine, molecular formula is C8H11N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 23: Cvclopropanesulfonic acid {17-[2-(6-isopropyl-2-pyridyl)-7-methoxy-8- methyl-quinolin-4-yloxy] – 13 -methyl-2, 14-dioxo-3 , 13 -diaza-tricyclo[ 13.3.0.O4’6] – octadec-7-ene-4-carbonyl} -amide (114). EPO 114A: Synthesis of 2-isopropylpyridine-iV-oxide (104).A mixture of isopropylpyridine (2.1 g, 17.75 mmol) and r¡ã-CPBA (5.0 g, 1.3 eq.) in CH2CI2 was stirred overnight at room temperature. Then, the reaction mixture was diluted with CH2CI2 (twice the volume) and successively washed with aqueous sodium bicarbonate (twice) and brine, dried (Na2SO4) and evaporated to give 2.0 g (85%) of the title compound 104.

The synthetic route of 644-98-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB; WO2007/14926; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem