Related Products of 607373-83-1 ,Some common heterocyclic compound, 607373-83-1, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 2-chloro-4-methoxy-5-nitropyridine (9.4 g, 50 mmol) and methylamine (35 wt.% in EtOH) (47 mL, 500 mmol) was stirred at 150C (microwave) for 15 min. The reaction mixture was allowed to cool to room temperature. Water (50 mL) was added. The resultant solid material was collected by filtration, washed with MeOH and then Et20 and dried in vacuo to give the desired compound. lH NMR delta (ppm)(CDCl3): 8.94 (1 H, s, ArH), 8.20 (1 H, s, NH), 5.33 (1 H, s, ArH), 5.24 (1 H, s, NH), 3.00 (3 H, d, CH3), 2.97 (3 H, d, CH3). LCMS (15cm_Formic_Ascemtis_HPLC_MeCN) Rt 6.24 (min) m/z 183 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 607373-83-1, 2-Chloro-4-methoxy-5-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoit Antoine; GENEY, Raphael Jean Joel; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart; WO2013/117645; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem