Duan, Jingli published the artcileBioequivalence of domestic and imported betahistine mesylate tablets in healthy volunteers, Product Details of C10H20N2O6S2, the publication is Zhongguo Linchuang Yaolixue Zazhi (2003), 19(1), 42-45, database is CAplus.
The objective of this study was to determine the bioequivalence of domestic and imported betahistine mesylate in 20 healthy volunteers. A single dose of 24 mg domestic and imported betahistine mesylate tablets was given according to an open randomized 2-way crossover design. Plasma concentration of the main metabolite of betahistine, pyridine-2-ethanoic acid, was determined by HPLC/MS/MS method. The pharmacokinetics parameters of the two products were as follow: Cmax 308.6 ± 208.8 mg L-1 and 339.4 ± 213.4 mg L-1; tmax 1.13 ± 0.66 h and 0.98 ± 0.47 h; AUC0-t 1168.5 ± 794.9 mg L-1 and 1129.3 ± 725.2 mg L-1; AUC0-∞ were 1213.2 ± 819.2 mg L-1 and 1178.9 ± 752.5 mg L-1, resp. The relative bioavailability of domestic product was (106.3 ± 29.1%). The results demonstrated that the two formations were bioequivalent by anal. of variance, two-one side test and 90% internal confidence.
Zhongguo Linchuang Yaolixue Zazhi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Product Details of C10H20N2O6S2.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem