Adding a certain compound to certain chemical reactions, such as: 164341-39-3, (5-(Trifluoromethyl)pyridin-2-yl)methanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 164341-39-3, blongs to pyridine-derivatives compound. Product Details of 164341-39-3
A mixture of the product of Example 18A (70 mg, 0.223 mmol), (5-(trifluoromethyl)pyridin-2-yl)methanamine (47.2 mg, 0.27 mmol), N-[(dimethylamino)-1H-1 ,2,3-triazolo- [4,5 -bj pyridin- 1 -ylmethylenel -N-methylmethanaminium hexafluorophosphate Noxide (HATU, 102 mg, 0.27 mmol), and triethylamine (0.062 mL, 0.45 mmol) in tetrahydrofuran (3 mL) was stirred for 16 hours. The reaction mixture was treated with water and brine and extracted with ethyl acetate. The combined organic layers were concentratedunder reduced pressure, and the residue was purified by reverse-phase HPLC performed on a Phenomenex Zorbax Rx-C18 column (250 x 21.2 mm, 7 im particle size) using a gradient of 10% to 95% acetonitrile/0.1% aqueous trifluoroacetic acid over 30 minutes at a flow rate of 18 mL/minute to provide the title compound (38.0 mg, 0.08 1 mmol, 36% yield). ?H NMR (501MHz, DMSO-d6) 5 ppm 8.89 (dt, J = 1.9, 1.0 Hz, 1H), 8.73 (s, 1H), 8.52 (t, J = 6.0 Hz, 1H),8.23-8.11 (m, 1H), 7.57-7.39 (m, 2H), 7.08 (dd, J = 11.4, 2.9 Hz, 1H), 6.86 (ddd, J = 9.0,2.9, 1.2 Hz, 1H), 4.48 (s, 2H), 4.43 (d, J = 6.0 Hz, 2H), 2.24 (s, 6H); MS (ESI) m/z 472.1 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,164341-39-3, (5-(Trifluoromethyl)pyridin-2-yl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; CALICO LIFE SCIENCES; ABBVIE, INC.; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina; FROST, Jennifer, M.; BLACK, Lawrence, A.; XU, Xiangdong; SWEIS, Ramzi, Farah; SHI, Lei; ZHANG, Qinwei, I; TONG, Yunsong; HUTCHINS, Charles, W.; CHUNG, Seungwon; DART, Michael, J.; (190 pag.)WO2017/193041; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem