Synthetic Route of 19798-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.
The second step,2- (4-methoxy-1H-indol-3-yl) -2-carbonylacetyl chloride was added to dichloromethane (20 mL)Solution, cooling to 0 ~ 5 stirring. A solution of 3-chloro-4-aminopyridine (1.28 g) and triethylamine (1.5 g) was added slowly to room temperature for 2 h. Cooling to 0 ~ 5 stirring 30min, filtration, filter cake with dichloromethane (5mL) washing; 40 blast drying to light yellow solid2- (4-methoxy-1H-indol-3-yl) -N- (3-chloropyridin-4-yl) -2-carbonylacetamide (2.0 g).
The chemical industry reduces the impact on the environment during synthesis 19798-77-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Yang Ying; Zhu Chenggen; Chen Qing; Jiang Jiandong; Cao Yingli; Guo Qinglan; Zhang Chao; Lin Sheng; Tang Ke; Yang Yongchun; Guo Jiamei; (140 pag.)CN107149603; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem