Electric Literature of 1008-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
809.9 g (3 mmol) of genistein, 60 ml of methanol, 240 muL (3 mmol) of 37% formaldehyde were added to a 100 ml round-bottomed flask, and stirred at 30 C. for 30 minutes under reflux.583.4 mg (3.6 mmol) of 1- (4-pyridyl) piperazine was added to a round bottom flask.Stir reflux at 35 C for 8h, and react at room temperature for 8h.The reaction was then stopped, suction filtered under reduced pressure, and solid-liquid separation.Collect the solid. The solid contains a small amount of 1-(4-pyridyl) piperazine.Formaldehyde and a small amount of genistein and products; the liquid contains genistein,1-(4-pyridyl)piperazine in methanol.Wash the solid 6 times with methanol, 10 ml of methanol each time,This gave 1022.8 mg of a white solid with a yield of 76.61%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1008-91-9, 1-(Pyridin-4-yl)piperazine.
Reference:
Patent; Beijing Normal University; Yan Xi; Yu Meixuan; Song Jinglei; (16 pag.)CN110483465; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem