Cobine, Caroline A. published the artcileRhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter, Application In Synthesis of 21829-25-4, the main research area is calcium transient smooth muscle cell internal analysis sphincter; gastrointestinal; interstitial cells of Cajal; pacemaker; slow wave; tone.
Ca2+ transients displayed ongoing rhythmic firings at both lengths and were abolished by nifedipine and the KATP channel activator pinacidil indicating their dependence upon CavL. Like SWs, CTs were greatest in frequency and amplitude at the distal extremity and conducted proximally. Removal of the distal IAS reduced but did not abolish CTs. The time constant for clearing cytoplasmic Ca2+ averaged 0.46 s and basal Ca2+ levels were significantly elevated. The similarities in spatiotemporal and pharmacol. properties of CTs and SWs suggest that SW gives rise to CTs while muscle stretch is not required. Elevated relative basal Ca2+ in the IAS is likely due to the inability of cells to clear or sequester Ca2+ between rapid frequency voltage-dependent Ca2+ entry events, i.e., conditions that will lead to tone development. The conduction of CTs from distal to proximal IAS will lead to orally directed contractions and likely contribute to the maintenance of fecal continence.
Neurogastroenterology & Motility published new progress about Cytoplasm. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application In Synthesis of 21829-25-4.