Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination with Pyridones was written by Tu, Hang-Fei;Nie, Yu-Han;Zheng, Chao;You, Shu-Li. And the article was included in Advanced Synthesis & Catalysis in 2022.Product Details of 626-64-2 This article mentions the following:
Herein a catalytic synthetic method for enantioenriched N-substituted pyridones was reported. By employing chiral iridium catalyst generated from the Carreira [P/olefin] ligand, intermol. asym. allylic amination of allyl alcs. with pyridones proceeded smoothly with excellent chemo-, regio- and enantioselectivities (>19:1 N/O, >19:1 b/l and ≥89% ee). The reaction was a kinetic resolution process under mild conditions and displayed a broad substrate scope for both pyridones and allylic alcs. The potential of this method was demonstrated by a gram-scale reaction with only 0.6 mol% catalyst loading and diverse transformations of the amination products to useful skeletons. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 626-64-2