Ionic liquids – reaction media and catalysts for synthesis of 1,4-dihydropyridines was written by Zicmanis, A.;Hinica, A.;Pavlovica, S.;Klavins, M.. And the article was included in Latvijas Kimijas Zurnals in 2009.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide This article mentions the following:
Ionic liquids (ILs) were evaluated as tunable solvents for the Hantzsch synthesis of 1,4-dihydropyridines (DHP) from 1,3-dicarbonyl compounds and hexamethylenetetramine. Structure changes of both cations and anions in ionic liquids allow design of the most suitable structure for the particular DHP synthesis. Increasing the hydrophobicity of the cation in the IL results in decreased yield of DHP; aromatic and aliphatic cations show similar performance; aromatic anions are slightly better than aliphatic ones; and more nucleophilic anions provide higher yield than other anions. Addition of buffer substances to the reaction mixture has a clearly pos. impact on the yield of DHP. Increased temperature results in higher yields of DHP. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application In Synthesis of 1-Dodecylpyridin-1-ium bromide).
1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide