The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles was written by Roy, Patrick J.;Dufresne, Claude;Lachance, Nicolas;Leclerc, Jean-Philippe;Boisvert, Michel;Wang, Zhaoyin;Leblanc, Yves. And the article was included in Synthesis in 2005.Category: pyridine-derivatives This article mentions the following:
A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a min. temperature The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chem. diversity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1Category: pyridine-derivatives).
2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives