Pyrazolopyridines. Part 5. Preparation and reactions of pyrazolo[3,4-c]pyridines was written by Chapman, David;Hurst, Jim. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1980.Safety of 2-Methoxy-4-methylpyridin-3-amine This article mentions the following:
Pyrazolopyridines I (R = H, R1 = Me, OMe, Cl; R = OMe, Cl, R1 = H) were prepared in good yield by nitrosation of the corresponding pyridines II, followed by rearrangement, cyclization and hydrolysis. The ring system readily underwent electrophilic substitution in the 3-position; I (R = Cl, R1 = H) was more susceptible to nucleophilic substitution than its isomer I (R = H, R1 = Cl). The 1- and 2-Ac and -Bz derivatives of I were prepared and their structures determined from spectral data. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Safety of 2-Methoxy-4-methylpyridin-3-amine).
2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 2-Methoxy-4-methylpyridin-3-amine