Electric Literature of 65156-94-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65156-94-7, name is 5-Chloro-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 5-chloro-lH-pyrrolo[3,2-b]pyridine (450 mg, 2.95 mmol, 1 equiv), Cs2C03 (960.9 mg, 2.95 mmol, 1 equiv) and iodomethane (418.6 mg, 2.95 mmol, 1.000 equiv) in DMF (11.2 mL), was stirred for 4 h at 60 C. The reaction was quenched by the addition of 30 mL of water, extracted with 10 ml of ethyl acetate and the combined organic layers concentrated under reduced pressure. The residue was purified by silica gel chromatography with ethyl acetate/petr oleum ether (1 : 10) as eluent to afford the desired final product as a yellow oil in 81% yield.
According to the analysis of related databases, 65156-94-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IDEAYA BIOSCIENCES, INC.; ALAM, Muzaffar; BECK, Hilary Plake; DILLON, Michael Patrick; GONZALEZ-LOPEZ, Marcos; RICO, Alice Chen; SUTTON, JR., James Clifford; (317 pag.)WO2019/18562; (2019); A1;,
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