Related Products of 1122-54-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1122-54-9, name is 4-Acetylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a 9 sodium hydride (60% in 10 paraffin oil) (1.98g, 0.049mol), 10mL of 11 Dimethyl formamide was added dropwise at 5C under nitrogen atmosphere. To this mixture, 12 4-acetylpyridine (3.0g, 0.024mmol) was added dropwise and stirred for 30min at ambient temperature. Then 13 diethyl oxalate (4.03mL, 0.029mol) was added slowly and the reaction mixture was again stirred for 3h at room temperature. The completion of the reaction was monitored by TLC and quenched with crushed ice. Then the reaction mixture was extracted with ethyl acetate (1x100mL), washed with water (100mL) and brine solution (100mL). The organic layer was separated, dried over anhydrous sodium sulfate and evaporation of solvent affords the expected intermediate 14 1. (White solid, Yield 78%). 1H NMR (300MHz, CDCl3) delta 8.78 (d, J=5.5Hz, 2H), 7.85 (d, J=5.5Hz, 2H), 4.42 (q, J=14.0, 7.1Hz, 2H), 1.42 (t, J=7.0Hz, 3H). 13C NMR (75MHz, CDCl3) delta 192.89, 173.26, 165.10, 150.57, 137.70, 122.79, 61.75, 29.62, 14.15.
According to the analysis of related databases, 1122-54-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Madhu; Sivakumar; Journal of Photochemistry and Photobiology A: Chemistry; vol. 371; (2019); p. 341 – 348;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem