Rhodium(III)-catalyzed chelation-assisted ortho-selective carbon-hydrogen alkylation of phenols with diazocarbonyl compounds involving a carbene migratory insertion process was written by Jiao, Lin-Yu;Ning, Zi-Hui;Yin, Xiao-Mei;Hong, Qian;Liu, Shanshan;Ma, Xiao-Xun. And the article was included in Catalysis Communications in 2021.Recommanded Product: 4783-68-0 This article mentions the following:
An efficient and convenient rhodium(III)-catalyzed chelation-assisted ortho-selective carbon-hydrogen bond alkylation of phenols treated with readily available diazocarbonyl compounds as the alkyl source has been described. Migratory carbene insertion represents the principal step to realize this carbenoid coupling transformation, giving rise to a broad rang of alkylated products and at the same time, releasing nitrogen gas as sole byproduct. This protocol offers exclusive regioselectivities, moderate to excellent chem. yields, and good functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 4783-68-0