Non-iminosugar glucocerebrosidase small molecule chaperones was written by Marugan, Juan Jose;Huang, Wenwei;Motabar, Omid;Zheng, Wei;Xiao, Jingbo;Patnaik, Samarjit;Southall, Noel;Westbroek, Wendy;Lea, Wendy A.;Simeonov, Anton;Goldin, Ehud;DeBernardi, Maria A.;Sidransky, Ellen. And the article was included in MedChemComm in 2012.Formula: C11H8BrN This article mentions the following:
Small mol. chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure-activity relationship (SAR), selectivity, cell activity and pharmacokinetics. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Formula: C11H8BrN).
2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C11H8BrN